FIGURE 3. Comparison of Pharmacokinetics and Pharmacodynamics Over Time, After Subcutaneous Injection of Insulin

IU = international unit; GIR = glucose infusion rate; PK = pharmacokinetics; PD = pharmacodynamics; SC = subcutaneous.
Reprinted with permission from Arnolds S, Kuglin B, Kapitza C, et al. How pharmacokinetic and pharmacodynamic principles pave the way for optimal basal insulin therapy in type 2 diabetes. J Clin Pract. 2010;64(10):1415-1424.